Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease
スポンサーリンク
概要
- 論文の詳細を見る
Total tau protein (t-tau) levels in cerebrospinal fluid (CSF) (CSF-tau) are markedly elevated in patients with Creutzfeldt-Jakob disease (CJD). Some CSF-tau may leak into the blood. We evaluated t-tau levels in serum (serum-tau) as a possible marker for the differential diagnosis of CJD from Alzheimer's disease (AD) and other rapidly progressive dementias (RPD). Serum- and CSF-tau levels were determined in patients with sporadic CJD (n = 12), AD (n = 10) and RPD but no CJD (non-CJD-RPD; n = 9) who showed RPD fulfilling the World Health Organization (WHO) criteria for possible CJD at onset and had a final diagnosis other than CJD. We also analyzed serum-tau levels in healthy volunteers as a control group (n = 10). Serum- as well as CSF-tau levels were significantly elevated in CJD group compared to those in AD, non-CJD-RPD and healthy control groups. Serum-tau would be a simple and useful marker to distinguish CJD from AD and non-CJD-RPD, requiring further large study to confirm this. © 2011 Springer-Verlag.
論文 | ランダム
- 484 小児思春期喘息寛解時の気道過敏性 : 吸入ステロイド治療の影響について(小児喘息(4), 第55回日本アレルギー学会秋季学術大会)
- 144 スギ減感作療法施行症例におけるスギ花粉飛散シーズン前後での血中マーカーの変化
- 入院治療を要したアトピー性皮膚炎の悪化に関連した医学的,社会的因子の検討 (主題 免疫・アレルギー・川崎病)
- 367 アトピー性皮膚炎児と正常児における血清TARC(CCL17)濃度の検討
- 277 小児気管支喘息患者の成人移行の危険因子(2)