Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil
スポンサーリンク
概要
- 論文の詳細を見る
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication. In order to establish the structural basis for such mutagenesis, the crystal structures of two kinds of DNA d(CGCGRATfUCGCG) with R = A/G have been determined by X-ray crystallography. The fU residues form a Watson-Crick-type pair with A and two types of pairs (wobble and reversed wobble) with G, the latter being a new type of base pair between ionized thymine base and guanine base. In silico structural modeling suggests that the DNA polymerase can accept the reversed wobble pair with G, as well as the Watson-Crick pair with A.
- Hindawi Publishingの論文
著者
-
TAKENAKA Akio
National Institute of Livestock and Grassland Science
-
竹中 昭雄
農業･食品産業技術総合研究機構畜産草地研究所
-
Takenaka A
National Institute Of Livestock And Grassland Science
-
竹中 昭雄
畜産草地研究所
-
竹中 昭雄
National Institute Of Livestock And Grassland Science
-
Takenaka A
Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Technology
-
Takenaka Akio
Department Of Life Science Faculty Of Bioscience And Biotechnology Tokyo Institute Of Tdechnology
-
Tsunoda Masaru
Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Technology
-
Ueno Y
Hokkaido Univ. Sapporo
関連論文
- The Effect of Protozoa on the Composition of Rumen Bacteria in Cattle Using 16S rRNA Gene Clone Libraries
- Difference in Structure of the Gene Encoding H^+-ATPase between Streptococcus bovis and Ruminococcus albus
- Difference in Structure of the Gene Encoding H^+-ATPase between Streptococcus bovis and Ruminococcus albus
- A-19 配列特異的SSU rRNA切断法を用いたウシルーメン細菌叢の定量的解析(ルーメン・消化管生態系,口頭発表)
- Molecular cloning, nucleotide sequence and characteristics of a xylanase gene (xynA) from Ruminococcus albus 7
- ルーメンプロトゾアが子牛の血漿ガストリン濃度に及ぼす影響
- Inhibitory effects of isoleucine and antagonism of the other branched-chain amino acids on fermentation parameters by mixed ruminal microbes in batch cultures and rumen simulating fermenters (Rusitec )
- Effects of amino nitrogen on fermentation parameters by mixed ruminal microbes when energy or nitrogen is limited
- ルーメン細菌叢に及ぼすプロトゾアの影響の分子生物学的手法による解析
- ルーメンプロトゾアの繊維分解酵素とその遺伝子解析
- Fiber Digestion by Rumen Ciliate Protozoa
- ル-メン内窒素代謝と生産性(6)窒素化合物の消化とル-メンプロトゾア
- ル-メンプロトゾアの機能と意義-7-プロトゾア構成とル-メン発酵および細菌叢との関係
- NDFと脂肪含有量に富む食品製造副産物の給与が泌乳前期の乳生産に及ぼす影響
- Crystal Structure of Eucaryotic E3, Lipoamide Dehydrogenase from Yeast^1
- Crystallization of Eukaryotic E3, Lipoamide Dehydrogenase, from Yeast, for Exhibiting X-Ray Diffraction beyond 2.5 A Resolution, and Preliminary Structure Analysis
- ル-メンプロトゾアの機能と意義-8-宿主に対するプロトゾアの機能
- A Simulation Model of Tree Architecture Development Based on Growth Response to Local Light Environment
- Crystallographic Studies on Damaged DNAs : III. N^4-Methoxycytosine Can Form Both Watson-Crick Type and Wobbled Base Pairs in a B-Form Duplex^1
- Structural Composition of Hammerhead Ribozymes
- Factors Controlling the Recruitment of Aster kantoensis (Asteraceae) : I. Breeding System and Pollination System
- Local coexistence of tree species and the dynamics of global distribution pattern along an environmental gradient : a simulation study
- Dynamics of seedling populations and tree species coexistence in a forest : a simulation study
- Crystal Structure of 3-Isopropylmalate Dehydrogenase from the Moderate Facultative Thermophile, Bacillus coagulans: Two Strategies for Thermostabilization of Protein Structures
- 酵母発酵培養物の添加が乳蛋白質生産,ル-メン発酵および血液性状に及ぼす影響
- Synthesis of 2'(3')-O-(L-Phenylalanyl) and 2'(3')-O-(D-Phenylalanyl) Cytidyly(3'-5')adenosine
- Comparison of effects of spatial autocorrelation on distribution predictions of four rare plant species in the Watarase wetland
- Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil
- 子牛のルーメン細菌および発酵パターンに及ぼすDasytricha EpidiniumおよびEntodiniumの影響
- 高エネルギー飼料給与時におけるホルスタイン種育成雌牛の発育および窒素出納に及ぼす飼料中粗タンパク質および第一胃非分解性タンパク質含量の影響
- Actinohivin : specific amino acid residues essential for anti-HIV activity
- Crystal Structure of Eucaryotic E3, Lipoamide Dehydrogenase from Yeast.