In Vitro and In Vivo Antimycobacterial Activity ofan Antihypertensive Agent Methyl-L-DOPA
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概要
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Methyl-L-DOPA, an antihypertensive agent, has significant in vitro activity against a variety of atypicalmycobacteria such as the Mycobacterium avium complex, M. scrofulaceum, M. xenopi and M. marinum, and rarepathogens like M. fortuitum. In the present investigation, the screening of the in vitro activity was further extended bytesting the in vitro activity against a total of 53 different strains of mycobacteria, including 34 clinical isolates of bothdrug-sensitive and drug-resistant Mycobacterium tuberculosis.Most of the strains were inhibited at 10-25 ?g/mLconcentrations of the drug. When methyl-L-DOPA wasinjected into male mice at a concentration of 10 ?g/g bodyweight (20 g each), methyl-L-DOPA significantly protectedthem when challenged with a 50 median lethal dose of M.tuberculosis H37Rv102. According to the ?2test, the in vivodata were highly significant (p<0.01).7p.
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