Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis.
スポンサーリンク
概要
- 論文の詳細を見る
The recent development of high-resolution DNA microarrays, in which hundreds of thousands of single nucleotide polymorphisms (SNPs) are genotyped, enables the rapid identification of susceptibility genes for complex diseases. Clusters of these SNPs may show runs of homozygosity (ROHs) that can be analyzed for association with disease. An analysis of patients whose parents were first cousins enables the search for autozygous segments in their offspring. Here, using the Affymetrix® Genome-Wide Human SNP Array 5.0 to determine ROHs, we genotyped 9 individuals with schizophrenia (SCZ) whose parents were first cousins. We identified overlapping ROHs on chromosomes 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17, 19, 20, and 21 in at least 3 individuals. Only the locus on chromosome 5 has been reported previously. The ROHs on chromosome 5q23.3-q31.1 include the candidate genes histidine triad nucleotide binding protein 1 (HINT1) and acyl-CoA synthetase long-chain family member 6 (ACSL6). Other overlapping ROHs may contain novel rare recessive variants that affect SCZ specifically in our samples, given the highly heterozygous nature of SCZ. Analysis of patients whose parents are first cousins may provide new insights for the genetic analysis of psychiatric diseases.
- 2011-05-31
論文 | ランダム
- 流出解析手法-15完-残された問題-土地利用変化に伴う流出変化(講座)
- 流出解析手法-14-低平地タンクモデルによる洪水解析(講座)
- 流出解析手法-13-低平地流出-タン水解析(講座)
- 流出解析手法-12-タンクモデルとSP法による最適同定(講座)
- 流出解析手法-11-SDFP法による貯留関数の最適同定(講座)