Demonstration of Three-Dimensional DNA Trapping Using Electric Force and Hydrodrag Force

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This paper describes the first demonstration of DNA trapping in a stacked three-dimensional (3D) microchannel. To carry out the 3D trapping of DNA by using electric force and hydrodrag force, a 3D microchip with a stacked structure is fabricated by the conventional rapid prototyping process and SU-8 peel-off process. Experimental results show that DNA trapping is observed on the application of electric potential with continuous pumping of DNA, but it is not observed in the absence of an electric potential. Further, the results suggest that the trapping throughput of DNA clearly depends on the capillary diameter but not on the flow rate. Thus, we conclude that, for a constant trapping area, reduction in the size of capillary structures with a high density results in an increase in the efficiency of DNA trapping.
2011-06-20