Effect of methotrexate on fracture healing
スポンサーリンク
概要
- 論文の詳細を見る
Low doses of methotrexate (MTX) are safe and effective for treating adult and juvenile rheumatoid arthritis. However, because this powerful anti-inflammatory drug might negatively influence the healing of wounds and fractures, MTX administration is often stopped during surgical procedures. The present study assesses the effects of low- and high-dose MTX on early inflammatory processes and bone healing in an experimental model of fracture.Thirty male Sprague-Dawley rats were assigned to low- and high-dose MTX and control groups. A femur was cut using a reciprocating saw and a 2-mm fracture gap was made using a fixator. One or four weeks thereafter, macrophages were immunostained and new bone formation was histomorphometrically measured.Significantly less new bone was formed in the high-dose MTX, than in the control group (p< 0.01), whereas bone formation did not significantly differ between the low-dose MTX and control groups. These results suggested that a low dose of MTX does not affect the early process of endochondral bone formation during fracture healing, whereas a high dose might delay the progress of new periosteal bone formation. Although more macrophages were found in the groups treated with MTX, their impact on surrounding inflammatory processes remains unclear.
論文 | ランダム
- 249 喘息予防・管理に関するアンケート調査.異なった患者集団の意識調査
- 伏見多美雄,福川忠昭,山口俊和共著, 経営の多目標計画 : 目標計画の考え方と応用例, 森北出版, 1987年6月刊, 199頁, 定価2400円
- 民法改正 民法(債権法)改正--法制審の審議状況について
- 246 掃除補助剤(市販品)の効果検討
- 消費者信用(金融) (2010年消費者法白書)