Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress
スポンサーリンク
概要
- 論文の詳細を見る
Background: To study the association between lipid-metabolism and depressive symptoms, genetic polymorphisms in serotonin transporter linked promoter region (5-HTTLPR) and fatty acid synthase gene (FASN) were investigated. Method: A cross-sectional study was conducted on 177 women (n = 166) and men (n = 15) recruited from workers in a hospital and nursing homes in Japan. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CES-D) scale and perceived psychological stress was measured using visual analogue scale (VAS). The genotypes of 5-HTTLPR (insertion/deletion; L/S), and FASN (Val1483Ile) were determined by the PCR methods. Linear regression analysis was performed, in which CES-D scores served as a dependent variable, and VAS scores, gene polymorphism, and confounders as independent variables. Results: Under the influence of perceived stress, S/S carriers of the 5-HTTLPR gene showed significantly higher CES-D scores in comparison with L/L + L/S carriers (F = 8.2, standardised β = 0.15, p < 0.05). Regression analysis also confirmed that CES-D scores in participants with Ile/Ile + Val/Ile genotypes of the FASN gene were significantly higher than those with Val/Val genotype (F = 8.4, standardised β = 0.16, p < 0.05). In relation to physical features, BMI among participants with S/S genotype of 5-HTTLPR was significantly lower compared with those with L/L + L/S genotypes. Conclusions: The Val1483Ile polymorphism in the FASN was associated with depressive symptoms under the influence of psychological stress. The S variant of 5-HTTLPR was related with less obese. © 2011 Elsevier B.V. All rights reserved.
論文 | ランダム
- アルミニゥム箔による断熱-2-
- 2,2'(1,3-Phnylene)bis(4-t-butyl-6-phenylphenylnitrene): An ESR Study of aQuintet Dinitrene Coupled with 1,3-Phenylene
- Synthesis and Characterization of Poly(1,3-phenylene)-Based Polyradical Carrying Cyclic Nitroxides. Observation of Ferromagnetic Interaction
- ゆるいスリーブを持つサウンディング装置による周辺抵抗調査の改善された方法 (オランダ式貫入試験機論文集(国際土質学会から))
- 壁面スパン方向運動による壁乱流組織構造の崩壊過程(安定性・乱流 乱流(1),一般講演)