Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51
スポンサーリンク
概要
- 論文の詳細を見る
The breast cancer susceptibility protein BRCA2 is essential for recombinational DNA repair. BRCA2 specifically binds to RAD51 via 8 BRC repeat motifs and delivers RAD51 to double-stranded DNA breaks. In this study, a mammalian two-hybrid assay and competitive ELISA showed that the interaction between BRC repeat 4 (BRC4) and RAD51 was strengthened by the substitution of a single BRC4 amino acid from valine to isoleucine (V1532I). However, the cancer-associated V1532F mutant exhibited very weak interaction with RAD51. This study used a comparative analysis of BRC4 between animal species to identify V1532 as an important residue that interacts with RAD51.
- 2011-06-23
論文 | ランダム
- 1436 オゾン水生成における気泡電位の影響(S38-2 気泡・粒子,S38 マイクロ・ナノフルイズ)
- 64. 胃粘膜内pH (gastric pHi)を用いた重症患者における組織酸素代謝の検討(第885回千葉医学会例会・千葉大学第二外科例会)
- 11402 新型マイクロバブル発生装置の高濃度オゾン水への応用(流体工学(1))
- 21403 三次元形状翼の前縁形状の違いがダイナミックリフトに及ぼす影響(流体工学(3))
- 21402 3次元円盤翼に働く非定常流体力と渦構造(流体工学(3))