The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats
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概要
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The antidepressant-like effect of tipepidine was studied in rats. Tipepidine at 20 and 40 mg/kg i.p. reduced immobility in the forced swimming test and tipepidine at 40mg/kg, i.p. increased climbing in the test. The drug at 40 mg/kg, i.p. had no effect on the loco-motor activity and motor coordination. These results suggest that tipepidine may be a novel drug with antidepressant-like activity.
- 2009-12-14
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