Tsukushi is required for anterior commissure formation in mouse brain

概要

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The anterior commissure (AC) is one of the important commissure projections in the brain thatconveys information from one side of the nervous system to the other. During development, theaxons from the anterior AC (aAC) and the posterior AC (pAC) course in the same dorsoventralplane and converge into a common fascicle for midline crossing. Previously, we reported thatTsukushi (TSK), a member of the secreted small leucine rich repeat proteoglycan family, functionsas a key coordinator of multiple pathways outside of cells through the regulation of an extracellularsignaling network. Here, we show evidence that TSK is critical for the formation of the AC. In micelacking TSK, the aAC and the pAC axons fail to cross the midline, leading to an almost totalabsence of the AC in adult mice. DiI labeling indicated that the aAC axons grew out from theanterior olfactory nucleus and migrated along normal pathways but never crossed the midline.Therefore, we have uncovered a crucial role for TSK for AC formation in the mouse brain.
2010-11-26