<Original Papers>Anti-inflammatory effects of Volatile Compound of Macrophage Migration Inhibitory Factor (MIF) Induction of Inflammatory in Macrophage Cell

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[Summary]Macrophage migration inhibitory factor (MIF) plays an important role in systemic local inflammatory and immune responses. Tumor necrosis factor-α (TNF-α)are major proinflammatory cytokines and is mainly products by monocytes and macrophages, and inducing the synthesis and release of many inflammatory mediators. It is involved in immune regulation, autoimmune diseases, and inflammation. Moreover, MIF is a counter regulator against corticosteroids. We previously assay that synthetic surfactant to inhibition of releases of proinflammatroy cytokines and then found the important characterization of releases of MIF. In this study, we tested to proinflammatory cytokines suppression of volatile compound to macrophage cells inducing MIF. As a result, carvone, eucarvone, karahanaenone, hinokitiol and a-camphorenaldhyde were inhibition to release of TNF-α from MIF-stimulated RAW 264.7 cells at concentration of 10μg/ml, respectively. Moreover, these compounds did not inhibit the release of TNF-α in THP-1 cells inducing LPS at tested concentrations. This result suggested that a specific pharmacological action should be involved in the inhibitory activity of these compounds. It seems that the compounds are direct acting MIF signal in cell.
近畿大学工学部の論文