Staphylococcus aureus requires cardiolipin for survival under conditions of high salinity
スポンサーリンク
概要
- 論文の詳細を見る
BackgroundThe ability of staphylococci to grow in a wide range of salt concentrations is well documented. In this study, we aimed to clarify the role of cardiolipin (CL) in the adaptation of Staphylococcus aureus to high salinity.ResultsUsing an improved extraction method, the analysis of phospholipid composition suggested that CL levels increased slightly toward stationary phase, but that this was not induced by high salinity. Deletion of the two CL synthase genes, SA1155 (cls1) and SA1891 (cls2), abolished CL synthesis. The cls2 gene encoded the dominant CL synthase. In a cls2 deletion mutant, Cls1 functioned under stress conditions, including high salinity. Using these mutants, CL was shown to be unnecessary for growth in either basal or high-salt conditions, but it was critical for prolonged survival in high-salt conditions and for generation of the L-form.ConclusionsCL is not essential for S. aureus growth under conditions of high salinity, but is necessary for survival under prolonged high-salt stress and for the generation of L-form variants.
論文 | ランダム
- Asymmetry Indexによる小児交叉咬合の咀嚼筋活動の評価
- エイズ痴呆と炎症性サイトカイン
- 宇宙と生命
- 生命の起源研究における未解決課題について
- 小児の咀嚼機能に関する総合的研究 : デンタルプレスケール^【○!R】およびグミゼリー^【○!R】を用いた咬合・咀嚼機能検査