アスピリンアレルギーに関する実験的研究第2編アスピリン蛋白の沈降反応に就いて

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On the Precipitation reactions in homologous and heterogous antigen-antibody systems, the author studied the immuno-chemical properties of aspirin between anti-aspirin-proteins rabbit sera with homologous antigen (bovine serum globulin-aspirin, human serum aspirin) and heterogous antigen (rabbit serum globulin-aspirin) as aspirin-protein conjugates. And also the inhibitory action of aspirylglycine on the antigen-antibody reaction was studied and the following results were obtained. 1. It is possible to confirm in vitro serological antigen-antibody reaction between the aspirin-protein conjugates and the anti-aspirin-protein rabbit sera. 2. It is also possible to confirm the immuno-chemical properties of aspirin from the cross reaction occurring in the antigen-antibody reaction. 3. From this immuno-chemical characteristic it has been possible to recognize that aspirin as a hapten possesses antigenicity. 4. In the above-mentioned cross reaction, inhibitory phenomenon by aspirylglycine is established. 5. The inhibitory phenomenon by aspirylglycine can be recognized not only in the antigen titer but also in the antibody titer.
1959-11-30