油症患者におけるPCB異性体の30数年間にわたる特異な残留

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特集号油症とPCB及び関連化合物研究報告第19集責任編集者古江増隆 / The Nineteenth Reports of the Study on Yusho and PCBs and Related Compounds Guest Editor Masutaka FurueConcentrations of polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB) and dichloro dichlorophenyl ethylen (DDE) in the blood of Yusho patients (n = 28) were statistically compared with those in the blood of Fukuoka residents (n = 151). The PCB concentrations in the blood of Yusho patients were higher than those of Fukuokacontrols and concentration ratios of Yusho/Control were various depending on PCB congeners, being 1.6 on 2,3',4,4',5-pentaCB (# 118), 17.5 on 2,3,3',4,4',5-hexaCB (# 156) and 5.4 on total PCBs. Correlation coefficients between age and concentrations of 7 PCB congeners, HCB and DDE in the blood of Fukuoka residents were significantly positive, each other (p < 0.001), while in Yusho patients, the correlation coefficients were positive but various depending on the congeners. However, correlation coefficient between PCB # 118 and PCB # 156 in the Yusho patients was remarkably low, indicating their peculiar accumulative properties in Yusho patients. The concentration of PCB # 118 had been markedly decreased after the ingestion of PCBs and would be metabolized to hydroxylated PCB, which might cause estrogen disturbance in the Yusho patients.
福岡医学会の論文
2003-05-25