流行性肝炎時の肝臓内Disse氏腔の病理組織学的研究 第3編 実験的犬肝障碍時のDisse氏腔について
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Eppinger, H. tried to endorse the inflammatory theory with the experimental of allyl formate, but there are not a few scholar expressed their opinions against the theory and also same differencies on Disses space are foung between autopsy and biopsy. Under the above sence, I studied histologically on the influence of DOCA using for epidemic hepatitis. 1. Searching mainly for the variation of Disses space on the dog's liver leaving at the room temperature, is not clearly shown in a short time, but it is clearly shown after 3 hours and it is remarkably observed after 24 hours. As for its living wall, it is mostly void but a light flocculatise substance is sometimes observed in it. Therefore, the general theory that Disses space being clear by the changeness after death night be agreeable. We, therefore, must accept the general theory, which the Disses space become clear by the changeness after death, put forward by many scholars. 2. Leaving the dog's liver toxicated by allylformate at the room temperature, the dilatation of Disses spaces is observed as same as the healthy one. On the other hand, observing closely for the fresh tissues, it is possible to observe the Disses space, and the serous exsudation and the imperturbability of homozeneaus substance or brownish blue granular material are found at the same place. But the dgree of it is not as clear as the one found in the liver of epidemic hepatitis. 3. Making the allylformate toxication on dogs, the expansion intermediate and the atrophy of the liver cells with the vacuolar dgeneration in a part or zones and peripheral zones vacuolar are observed, and the capillary vessels are remarkably limited, interrupted and partly obliterated and staynative hyperemia is fouud. 4. If DOCA is given to the dogs, at that time, the above changes are improved according to the dosis. The degeneration of the liver parenchym is light with a small amount of DOCA, and the capillary vessels is normal or becomes a little narrow, and it is not observed even a little with the big dosis and the capillary vessels is rather dilated and the blood circulation is increased. 5. It is, therefore, clear that the influences of DOCA on the dogs toxicated with allyl-formate is remarkable and DOCA acts upon the vascular system and improves the changes of the liver parenchyms.
- 1958-04-30
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