Carotenoids as regulators for inter-species difference in Cytochrome P450 1A expression and activity in ungulates and rats
スポンサーリンク
概要
- 論文の詳細を見る
Ungulates (deer, cattle and horses) are reported as animal species which show extreme-accelerated metabolism of CYP1A substrates, such as ethoxyresorufin compared to rats. This study was undertaken to investigate whether accumulation of carotenoids is a possible cause for inter-species difference in CYP1A-dependent activity in this group of animals. The relationship between inter-species differences in CYP1A-dependent activity and the accumulated carotenoids and retinoids as candidates of dietary CYP1A inducers in ungulate species was clarified. Interestingly, there were positive correlations between the accumulated carotenoids, such as β-carotene, with both EROD activity and CYP1A protein expression. These correlations were negative with the accumulated retinoids, such as retinol. The β-carotene was major component of carotenoids in ungulates, and known as an inducer of CYP1A. On the other hand, the retinol is reported as the inhibitor of CYP1A. Other factors which affect CYP1A1 expression, such as polycyclic aromatic hydrocarbons, were also analyzed. To cancel the effects of inter-species difference in CYP1A induction signal cascade among these animals, the rat cell line (H4-II-cells) was treated with the extracted carotenoids from the examined animals. In conclusion, carotenoids and retinoids may have direct effects on the inter-species differences in CYP1A-dependent activity and protein expression.
論文 | ランダム
- Methotrexate 血液中濃度測定 (酵素免疫法) と輸液中での安定性
- W-II-5 小児悪性腫瘍患児の栄養管理について
- 5281 阪神・淡路大震災で被災した瓦屋根の修理工事の調査(その2) : 修理前後における構法の比較
- 進行性骨化性筋炎に対するEHDP治療 (第54回中部日本整形外科災害外科学会-1-) -- (代謝・系統疾患)
- 5280 阪神・淡路大震災で被災した瓦屋根の修理工事の調査(その1) : 瓦屋根の被害状況