Roles of the Primate Motor Thalamus in the Generation of Antisaccades
スポンサーリンク
概要
- 論文の詳細を見る
In response to changes in our environment, we select from possible actions depending on the given situation. The underlying neural mechanisms for this flexible behavioral control have been examined using the antisaccade paradigm. In this task, subjects suppress saccades to the sudden appearance of visual stimuli (prosaccade) and make a saccade in the opposite direction. Because recent imaging studies showed enhanced activity in the thalamus and basal ganglia during antisaccades, we hypothesized that the corticobasal ganglia loop may be involved. To test this, we recorded from neurons in the paralaminar part of the ventroanterior (VA), ventrolateral (VL) and mediodorsal (MD) nuclei of the thalamus when 3 monkeys performed pro/antisaccade tasks. For many VL and some VA neurons, the firing rate was greater during anti-than prosaccades. In contrast, neurons in the MD thalamus showed much variety of responses. For the population as a whole, neuronal activity in the VA/VL thalamus was strongly enhanced during antisaccades compared with prosaccades, while activity in the MD nucleus was not. Inactivation of the VA/VL thalamus resulted in an increase in the number of error trials in the antisaccade tasks, indicating that signals in the motor thalamus play roles in the generation of antisaccades. Enhancement of firing modulation during antisaccades found in the thalamus and those reported previously in the supplementary eye field and the basal ganglia suggest a strong functional linkage between these structures. The neuronal processes through the thalamocortical pathways might be essential for the volitional control of saccades.
- 2010-04-07
論文 | ランダム
- 代理母出産の倫理問題に対する看護学生のとらえ方 (特集 周産期の医療・看護と生殖補助医療)
- 263 代理母の倫理的社会的問題と児の福利についての看護学生の意識(不妊1)(第45回日本母性衛生学会総会学術集会)
- 生殖補助医療によって生まれた「児の出自を知ること」についての考察
- リンゴ，ナシ，モモ及びブドウの葉の純光合成速度とその関連要素について
- リンゴ,ナシ,モモ及びブドウの葉の純光合成速度とその関連要素について