[原著］Specific immunosuppression without genetic restriction in vivo due to spleen extract and diluted antiserum

概要

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The effect of spleen extract and diluted antiserum to antibody production was studied in order to clarify the role of spleen extract in regulation of antibody production. Extracts of normal or pertussis-vaccine-stimulated mouse spleen did not by themselves suppress the primary immune response of mice to sheep or horse red blood cells. Similarly, anti-sheep-red-blood-cell mouse serum did not suppress if administered after 20- to 50-fold dilution. However, when the spleen extract and the diluted antiserum were administered either together with, or a day before the antigen, a very strong suppression of the primary response was observed. Antibody production was not suppressed by a combination of kidney or liver extracts and diluted mouse antisera. The suppressive action observed was specific, and the specificity was determined solely by the specificity of the diluted antiserum used. On the other hand, the stimulatory action of the spleen extract appeared non-specific. Indeed not only mouse spleen extracts but also rat spleen extracts or concentrated bovine spleen extracts exerted a suppressive action on antibody production in mice. The secondary response was suppressed very effectively by the administration of spleen extracts alone. From the above-mentioned results, it was clarified that a specific immunosuppression without genetic restriction was due to spleen extract and diluted antiserum in vivo.
琉球大学医学部の論文
1982-00-00