Syntheses and Characterization of Polymers Containing Nucleic Acid Bases
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概要
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Two different types of the polymers containing nucleic acid bases in backbone or in pendant groups were prepared. The polymers of the first type were polyureas obtained by the polyaddition reaction of uracil and adenine with hexamethylene diisocyanate (HMDI). The second type, that is cationic polyurethanes containing nucleic acid bases in pendant groups, were obtained by Menschutkin reaction of halogenated derivatives of uracil and adenine with a linear polyurethane containing, tertiary nitrogen atoms which was based on HMDI and N-methyldiethanolamine. Base-base interactions were studied for the polymers by UV and NMR spectra. A relatively high value of hypochromicity, ca. 19%, was observed for the mixture of the ionic polyurethane with uracil pendant and herring sperm DNA. Complementary hydrogen bonding interaction was detected for the mixture of the ionic polyurethane with adenine pendant and that with uracil pendant. Nonthrombogenic character of the polymers was examined according to the modified Lee-White method. The ionic polyurethanes with adenine and uracil pendant exhibited fairly good anti-clotting property.
- 長崎大学工学部の論文
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