Radiation damage to the normal monkey brain: experimental study induced by interstitial irradiation.
スポンサーリンク
概要
- 論文の詳細を見る
<p>Radiation damage to normal brain tissue induced by interstitial irradiation with iridium-192 seeds was sequentially evaluated by computed tomography (CT), magnetic resonance imaging (MRI), and histological examination. This study was carried out in 14 mature Japanese monkeys. The experimental area received more than 200-260 Gy of irradiation developed coagulative necrosis. Infiltration of macrophages to the periphery of the necrotic area was seen. In addition, neovascularization, hyalinization of vascular walls, and gliosis were found in the periphery of the area invaded by the macrophages. All sites at which the vascular walls were found to have acute stage fibrinoid necrosis eventually developed coagulative necrosis. The focus of necrosis was detected by MRI starting 1 week after the end of radiation treatment, and the size of the necrotic area did not change for 6 months. The peripheral areas showed clear ring enhancement with contrast material. Edema surrounding the lesions was the most significant 1 week after radiation and was reduced to a minimum level 1 month later. However, the edema then expanded once again and was sustained for as long as 6 months. CT did not provide as clear of a presentation as MRI, but it did reveal similar findings for the most part, and depicted calcification in the necrotic area. This experimental model is considered useful for conducting basic research on brachytherapy, as well as for achieving a better understanding of delayed radiation necrosis.</p>
論文 | ランダム
- ヒト歯周炎罹患歯肉におけるTIMP-1, TIMP-2およびCollagenase mRNA発現の検索
- B-16-1140 ヒト歯肉におけるCollagenase及びCollagenase inhibitor mRNA発現の検索
- 鋼管杭の動的載荷試験に関する考察 (現地試験特集)
- 新しい下水道管補修材料の開発
- 塩基性アンモニア浴からのBi_2Te_3薄膜の電析と熱電特性