Automated direct assay system for RU38486, an antiprogesterone-antiglucocorticoid agent, and its metabolites using high performance liquid chromatography.
スポンサーリンク
概要
- 論文の詳細を見る
<p>An automated direct assay system using high performance liquid chromatography was developed for the measurement of RU38486 and its three metabolites (RU42698, RU42848, RU42633) in human serum. Serum concentrations of these compounds were measured up to 144 h following single oral administration of 200 (200 mg group, n = 3) or 400 mg (400 mg group, n = 3) of RU38486 to healthy female volunteers. The serum half-lives (200 mg group-400 mg group) of RU38486, RU42698, RU42848 and RU42633 were 31.8-33.1 h, 41.2-39.3 h, 33.9-36.6 h and 29.2-36.6 h, respectively. Our system could quantify them easily and simultaneously, and was considered to be valuable in studies on the relationship between the pharmacokinetics and the clinical effects of RU38486.</P></p>
論文 | ランダム
- Kinetic EquationのT≃T_cでのふるまい(^3Heの超流動の動的諸問題,研究会報告)
- Miscoding activities of biologically inactivated kanamycins(Communications to the editors)
- 最近の農業における航空機リモートセンシングとGIS技術の利用
- Unified Theory of Relaxations in Plasmas
- 1 PRO'S AND CON'S OF DIFFERENT THE RAPEUTIC APPROACHES(6 アレルギ-疾患の早期治療介入)