A sheep survived for 48 days with the biventricular bypass type total artificial heart.
スポンサーリンク
概要
- 論文の詳細を見る
<p>A biventricular bypass type total artificial heart (BVB-TAH) utilizing two pusher-plate pumps was developed and implanted in a sheep for 48 days with excellent results. A Hall effect sensor was utilized to operate each pump independently with a full stroke at variable rates (VR). With this system, the animal's hemodynamics was kept physiologically, and all metabolic parameters except hemoglobin and hematocrit returned to normal three weeks after implantation. However, signs of infection appeared on the forty-second day, and consequently the animal fell into a state of shock. Even at that time the BVB-TAH maintained circulation by increasing pumping rate automatically. On the forty-eighth day, the animal could not stand and suffered from anuria; the experiment was then terminated after 1,140 h pumping. At autopsy, there was an enlarged heart with an atrophic change, 1,900 ml of pleural effusion, and 3,100ml of ascites fluid. Blood culture taken on the forty-seventh day yielded Acinetobacter calcoaceticus. The BVB-TAH operated in an independent VR mode maintained entire circulation, and has a capability of substituting the native heart function in any situation.</p>
論文 | ランダム
- 二期的に心室瘤切除を行った亜急性心臓破裂の1例
- 腎摘出後に生じた腎動静脈瘻による心不全の1例
- 短期間に形成された収縮性心膜炎の1例
- 心室中隔膜性部に瘤状構造を形成した3例
- 160)他臓器疾患を伴なう開心術症例の検討 : 日本循環器学会第59回近畿地方会