Plasma brain natriuretic peptide and the evaluation of volume overload in infants and children with congenital heart disease.
スポンサーリンク
概要
- 論文の詳細を見る
<p>This study was designed to explore whether it was possible to evaluate the severity of VSD, PDA, and ASD by measuring brain natriuretic peptide (BNP) levels. We also investigated normal BNP levels in children to provide a baseline for our study. We measured BNP levels in 253 normal children, including 11 normal neonates, and in 91 VSD patients, 29 PDA patients, and 34 ASD patients. BNP levels showed no age-related differences in normal children (the mean value: 5.3 +/- 3.8 pg/ml). In the healthy neonates, BNP levels rose from 10.4 +/- 11.9 pg/ml in cord blood to 118.8 +/- 83.2 pg/ml on day 0, then fell to 15.3 +/- 7.8 pg/ml by day 7. In VSD and PDA patients, BNP levels correlated significantly with Qp/Qs, LVEDV, and peak RVP/LVP. In ASD patients, BNP levels correlated with Qp/Qs and RVEDV. Especially, in VSD patients, as an index corresponding to 1.5-2.0 of the Qp/Qs ratio, BNP levels of 20-35 pg/ml were found to be best with regard to both sensitivity and specificity. In the healthy neonates, BNP levels changed rapidly after birth. In VSD, PDA, and ASD patients, BNP levels were well-correlated with the severity of the disease. Especially, in VSD patients, it that appears BNP levels may be useful in evaluating surgical indications, with 20-35 pg/ml levels being the appropriate cut-off value.</p>
論文 | ランダム
- 高齢者医療確保法と特定健康診査・特定保健指導 : いわゆるメタボ健診の開始
- Origin of the Improved Performance of High-Deposition-Rate Microcrystalline Silicon Solar Cells by High-Pressure Glow Discharge
- Suspicious influence of thymectomy on skin papilloma induction
- Petrogenesis of orthopyroxene- and amphibole-bearing andesites, Mustique, Grenadine Islands, Lesser Antilles Arc : Isotope, trace element and physical constraints
- 産業集積地域の苦悩と自立 (特集 日本の産業を支えるものづくり--産業空洞化と地域産業の苦悩と自立)