Positive association of AKT1 haplotype to Japanese methamphetamine use disorder

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<p>Recent evidence suggests that the AKT1-GSK3b signalling cascade partially mediates dopaminedependentbehaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth)use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associationsof SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the associationbetween AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182patients and 437 controls). A positive association between a SNP and haplotypes was found, and the‘signal’ SNP was the same SNP found to be associated with US schizophrenia, but not with Japaneseschizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-usedisorder. Further investigation of these associations, together with evidence from previous animal studies,may open the way to elucidation of the pathophysiology of this condition.</p>
2007-10-22