慢性関節リウマチとT-リンパ球―末梢血,関節液中の分布と免疫抑制剤のおよぽす影響について―

概要

論文の詳細を見る
Gradient centrifugation was quite useful in obtaining "mononuclear" cell fractions from synovial fluids derived from patients with rheumatoid arthritis. The ratio of lymphocytes to monocytoid cells was similar to that seen in peripheral blood. Prior treatment of the fluid with hyaluronidase was found to be necessary to obtain a satisfactory yield of the cells. Sheep erythrocyte rosette-forming lymphocytes (T-cells) were studied in 18 paired samples of synovial fluid and blood in RA and 15 control blood samples from normal persons were also examined. In the paired synovial fluid and blood samples from the RA patients, the mean percentages of the T-cells were 56.6 and 47.1 respectively and the difference was statistically significant (0.01<p<0.05). There was no significant difference between T-cell percentages in rheumatoid and control peripheral blood. In two RA patients receiving cyclophosphamide over an average period of 20 weeks, sequential studies of T-cells were performed on both the blood and synovial fluid. By the tenth week of treatment, they were markedly reduced in both synovial fluid and peripheral blood. By the 12th to the 15th week, however, at a time when the cumulative dose of cyclophosphamide was 5,000 mg, a rebound increase in T-cells was observed in the synovial effusion. The numbers of the T-cells in the blood concomitantly showed only a minimal rebound.
岡山大学温泉研究所の論文
1978-03-25