Identification of a vesicular nucleotide transporter
スポンサーリンク
概要
- 論文の詳細を見る
<p>ATP is a major chemical transmitter in purinergic signal transmission. Before secretion, ATP is stored in secretory vesicles found in purinergic cells. Although the presence of active transport mechanisms for ATP has been postulated for a long time, the proteins responsible for its vesicular accumulation remains unknown. The transporter encoded by the human and mouse SLC17A9 gene, a novel member of an anion transporter family, was predominantly expressed in the brain and adrenal gland. The mouse and bovine counterparts were associated with adrenal chromaffin granules. Proteoliposomes containing purified transporter actively took up ATP, ADP, and GTP by using membrane potential as the driving force. The uptake properties of the reconstituted transporter were similar to that of the ATP uptake by synaptic vesicles and chromaffin granules. Suppression of endogenous SLC17A9 expression in PC12 cells decreased exocytosis of ATP. These findings strongly suggest that SLC17A9 protein is a vesicular nucleotide transporter and should lead to the elucidation of the molecular mechanism of ATP secretion in purinergic signal transmission. </p>
- 2008-04-01
論文 | ランダム
- H.v.クライスト『ミヒャエル・コールハース』注釈への一つの試み
- 海と糸杉 : H.v.クライスト「ローベルト・ギスカルト」論(2) : その譬喩と形象性の問題
- ハインリッヒ・フォン・クライスト「ローベルト・ギスカルト論」(1) : その演劇的技法について
- 東海大学学生の外国語に対する意識の調査とその考察 : ドイツ語履修者の場合
- 細線加熱法による流体の粘度測定とそれを応用したチ-ズ・カ-ドメ-キング工程の自動計測管理