全身性エリテマトーデスにおけるa1ternative pathwayに関する研究 ウサギ赤血球溶血反応を利用して 第2編 臨床的考察
スポンサーリンク
概要
- 論文の詳細を見る
Hemolytic activity of the total alternative complement pathway(ACH50), properdin activity(P activity) and Factor B activity(B activity) were measured in 64 systemic lupus erythematosus(SLE) patients using rabbit red blood cells. The following results were obtained. 1) ACH50, P activity and B activity were significantly lower in SLE patients than in normal subjects. 2) ACH50 correlated with CH50, C3, Factor B, B activity, C5 and P activity. P activity correlated only with ACH50. B activity correlated with ACH50, CH50, C3 and Factor B. 3) CH50, C4, C3, Factor B correlated with each other. 4) The degree of ACH50 reduction was less than that of CH50 reduction in the active stage of SLE. These findings suggest that the alternative complement pathway was activated mainly by the C3b positive feedback mechanism possibly due to triggering by immune complexes in vivo. The alternative complement pathway might play a part in defence mechanisms instead of decrease in the classical complement pathway in the active stage of SLE.
- 1981-12-30
論文 | ランダム
- 新・一書一会 「彼方より」をめぐって 新しいジル・ド・レ像を描く
- "バイボラック"(高分子重合反応装置)の性能特性
- (3) SLEにおけるANFの病因的意義
- 鉛蓄電池の革新
- Discrimination among Amino Acids Using an Amperometric Biosensor Based on Electrochemical Nonlinearity