The Effect of N-acetylcysteine on Biomarkers for Radiation-Induced Oxidative Damage in a Rat Model
スポンサーリンク
概要
- 論文の詳細を見る
<p>Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparingits biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors,in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000mg/kg NAC) and R+WR-2721 (received irradiation and 200mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p<0.01). Tissue MDA levels of R+NAC and R+WR-2721 rats decreased compared to R rats (p<0.01;p<0.05, respectively). Tissue MPO activities of R+NAC and R+WR-2721 rats were higher than those of R rats (p<0.001). Serum MPO levels of R+WR-2721 rats were lower than those of C rats and R rats (p<0.01, p<0.001, respectively). In conclusion, the study suggests that the radioprotective effect against radiation-induced oxidative damage of NAC may be similar to that of WR-2721.</p>
論文 | ランダム
- スクープ!! ここまでひどいかマンション販売 伊藤忠お粗末「不適格」億ション
- 首都圏マンション供給減 都心の優良物件売り惜しみバブルの再来 (不動産バブル)
- "ICT武装"が進む分譲マンションの最前線(第4回)管理組合による電子決議と電子文書の活用法
- 信託受託基準厳格化がファンドに与えた影響と脚光を浴びる再生プレーヤーの取組み (特集 新たなビジネスチャンスは中古市場にあり 動きはじめた中古マンション流通市場)
- CASE STUDY 中古マンション市場を活性化する担い手たち (特集 新たなビジネスチャンスは中古市場にあり 動きはじめた中古マンション流通市場)