The Effect of N-acetylcysteine on Biomarkers for Radiation-Induced Oxidative Damage in a Rat Model
スポンサーリンク
概要
- 論文の詳細を見る
<p>Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparingits biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors,in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000mg/kg NAC) and R+WR-2721 (received irradiation and 200mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p<0.01). Tissue MDA levels of R+NAC and R+WR-2721 rats decreased compared to R rats (p<0.01;p<0.05, respectively). Tissue MPO activities of R+NAC and R+WR-2721 rats were higher than those of R rats (p<0.001). Serum MPO levels of R+WR-2721 rats were lower than those of C rats and R rats (p<0.01, p<0.001, respectively). In conclusion, the study suggests that the radioprotective effect against radiation-induced oxidative damage of NAC may be similar to that of WR-2721.</p>
論文 | ランダム
- 離陸する和製M&A (特集 それでも世界で勝つ--渾身のグローバル経営8社)
- 25pGAA-2 極限環境発生の最前線(25pGAA 領域6,領域10,領域12合同シンポジウム:構造研究の新展開-極端条件と不規則系,領域12(ソフトマター物理,化学物理,生物物理))
- 海洋性細菌由来シアル酸転移酵素の機能解析と利用 : シアル酸含有糖鎖の発酵生産に成功
- ヨウ化サマリウムを用いた6-Endo-Trig型の環化反応によるヒドリンダノン類縁体の合成
- 化合物の形と反応のかたち(3)アルコール/ケトンの酸化還元反応の立体化学的考察