The Effect of N-acetylcysteine on Biomarkers for Radiation-Induced Oxidative Damage in a Rat Model
スポンサーリンク
概要
- 論文の詳細を見る
<p>Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparingits biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors,in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000mg/kg NAC) and R+WR-2721 (received irradiation and 200mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p<0.01). Tissue MDA levels of R+NAC and R+WR-2721 rats decreased compared to R rats (p<0.01;p<0.05, respectively). Tissue MPO activities of R+NAC and R+WR-2721 rats were higher than those of R rats (p<0.001). Serum MPO levels of R+WR-2721 rats were lower than those of C rats and R rats (p<0.01, p<0.001, respectively). In conclusion, the study suggests that the radioprotective effect against radiation-induced oxidative damage of NAC may be similar to that of WR-2721.</p>
論文 | ランダム
- O-3-113 術前放射線化学療法により根治切除を施行しえた肝門部胆管癌の1例(胆・膵 集学的治療1,一般演題(口演),第63回日本消化器外科学会総会)
- WS-2-2-7 膵頭十二指腸切除術後の膵管非拡張例における膵管空腸粘膜吻合no stent法(ワークショップ2-1 膵頭十二指腸切除術の再建法,吻合法の提案と課題,第63回日本消化器外科学会総会)
- 第23回国際測地学・地球物理学連合総会及び第23回国際測地学協会総合報告
- W-9-7 stageIVa膵癌の治療戦略(ワークショップ9 Stage IVa膵癌の治療戦略,第62回日本消化器外科学会定期学術総会)
- 第22回国際測地学・地球物理学連合総会及び第22回国際測地学協会総会報告