The Effect of N-acetylcysteine on Biomarkers for Radiation-Induced Oxidative Damage in a Rat Model
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<p>Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparingits biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors,in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000mg/kg NAC) and R+WR-2721 (received irradiation and 200mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p<0.01). Tissue MDA levels of R+NAC and R+WR-2721 rats decreased compared to R rats (p<0.01;p<0.05, respectively). Tissue MPO activities of R+NAC and R+WR-2721 rats were higher than those of R rats (p<0.001). Serum MPO levels of R+WR-2721 rats were lower than those of C rats and R rats (p<0.01, p<0.001, respectively). In conclusion, the study suggests that the radioprotective effect against radiation-induced oxidative damage of NAC may be similar to that of WR-2721.</p>
論文 | ランダム
- 定常状態熱力学(第2セッション[定常状態熱力学],基研研究会「非平衡系の新局面-運動・機能・構造-」,研究会報告)
- I. Prigogine 著, 安孫子誠也, 谷口佳津宏訳, 確実性の終焉; 時間と量子論, 二つのパラドクスの解決, みすず書房, 東京, 1997, vi+200p., 21.5×15cm, 本体3,400円 [一般書]
- くりこみ群になにができるか(基研研究会「統計物理の展望」,研究会報告)
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