The Effect of N-acetylcysteine on Biomarkers for Radiation-Induced Oxidative Damage in a Rat Model
スポンサーリンク
概要
- 論文の詳細を見る
<p>Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparingits biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors,in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000mg/kg NAC) and R+WR-2721 (received irradiation and 200mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p<0.01). Tissue MDA levels of R+NAC and R+WR-2721 rats decreased compared to R rats (p<0.01;p<0.05, respectively). Tissue MPO activities of R+NAC and R+WR-2721 rats were higher than those of R rats (p<0.001). Serum MPO levels of R+WR-2721 rats were lower than those of C rats and R rats (p<0.01, p<0.001, respectively). In conclusion, the study suggests that the radioprotective effect against radiation-induced oxidative damage of NAC may be similar to that of WR-2721.</p>
論文 | ランダム
- 22aVC-6 確率共鳴に基づいた温度制御(22aVC その他の系,領域11(統計力学,物性基礎論,応用数学,力学,流体物理))
- 23aWF-7 確率共鳴のON-OFF制御系への導入(その他の系,領域11,統計力学,物性基礎論,応用数学,力学,流体物理)
- 26aXE-6 確率共鳴による温度制御II(26aXE 確率過程・確率モデル(パーコレーションを含む),領域11(統計力学,物性基礎論,応用数学,力学,流体物理))
- 23aWA-6 大学初年度における力学実験装置の開発(23aWA 物理教育,領域13(物理教育,物理学史,環境物理))
- 26aXE-5 アクチュエータの確率的制御(26aXE 確率過程・確率モデル(パーコレーションを含む),領域11(統計力学,物性基礎論,応用数学,力学,流体物理))