The Effect of N-acetylcysteine on Biomarkers for Radiation-Induced Oxidative Damage in a Rat Model
スポンサーリンク
概要
- 論文の詳細を見る
<p>Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparingits biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors,in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000mg/kg NAC) and R+WR-2721 (received irradiation and 200mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p<0.01). Tissue MDA levels of R+NAC and R+WR-2721 rats decreased compared to R rats (p<0.01;p<0.05, respectively). Tissue MPO activities of R+NAC and R+WR-2721 rats were higher than those of R rats (p<0.001). Serum MPO levels of R+WR-2721 rats were lower than those of C rats and R rats (p<0.01, p<0.001, respectively). In conclusion, the study suggests that the radioprotective effect against radiation-induced oxidative damage of NAC may be similar to that of WR-2721.</p>
論文 | ランダム
- 共沸蒸留プロセスのためのエントレーナ選択支援システムの開発
- High-Dispersion Spectra of NH_2 in the Comet C/1999 S4 (LINEAR) : Excitation Mechanism of the NH_2 Molecule
- Gas-to-Dust Ratio of Two Comets : Implication for Inhomogeneity of Cometary Nuclei?
- Chiral Distortion of Di(μ-sulfido)-bis[oxomolybdenum(V)] Complexes of a Hexadentate Ligand N,N,N',N'-Tetrakis(2-pyridylmethyl)-R-propylenediamine and Its Analogs
- Comparative Structural, Spectroscopic and Redox Studies of Isostructural Complexes of Ruthenium(III), Osmium(III), and Rhenium(III): cis-Dichloro Complexes Containing Tris(2-Pyridylmethl)amine and Its 6-Methylpyridyl Derivative