経皮吸収からみた化粧品の有用性評価の現状と課題

概要

論文の詳細を見る
The stratum corneum, uppermost layer of skin, functions as a primary barrier against the penetration of cosmetic ingredients. The amount and rate of percutaneous penetration of cosmetic ingredients are important determinants for their efficacy. When cosmetic formulations are applied on the skin surface, entrapped cosmetic ingredients are generally distributed from their formulations into the skin tissues and permeated through the skin barrier by simple diffusion. These profiles are mathematically expressed by Fick’s law of diffusion. Skin permeation of lipophilic compounds is higher than that of hydrophilic compounds. Molecular weight is also an index to affect the skin permeation profiles of chemicals. Only low molecules usually less than 500 Da can be penetrated into the skin membrane. Analysis of these profiles of cosmetic ingredients is very important to develop functional cosmetics and cosmeceuticals.