Promotion of direct reprogramming by transformation-deficient Myc
スポンサーリンク
概要
- 論文の詳細を見る
形質転換活性を欠損したMycによるリプログラミング促進効果：L-Mycを用いた効率的なiPS細胞の樹立. 京都大学プレスリリース. 2010-07-27. http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2010/100727_1.htmInduced pluripotent stem cells (iPSCs) are generated from mouse and human fibroblasts by the introduction of three transcription factors: Oct3/4, Sox2, and Klf4. The proto-oncogene product c-Myc markedly promotes iPSC generation, but also increases tumor formation in iPSC-derived chimeric mice. We report that the promotion of iPSC generation by Myc is independent of its transformation property. We found that another Myc family member, L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc. In mice, L-Myc promoted germline transmission, but not tumor formation, in the iPSC-derived chimeric mice. These data demonstrate that different functional moieties of the Myc proto-oncogene products are involved in the transformation and promotion of directed reprogramming.
- 2010-07-26
論文 | ランダム
- 所得税法二五条二項二号の規定と憲法二九条一項,八四条(最判昭和57.12.21)
- 所得税法二五条二項二号の規定は,憲法二九条一項・八四条に違反しない(最判昭和57.12.21)
- 診療放射線技師及び診療エックス線技師法二四条による規制の範囲と憲法二二条一項,二五条(最判昭和58.7.14)
- 奈良時代貴族の邸宅跡--平城京左京五条二坊十四坪
- 1.刑法一七五条と憲法二一条 2.刑法一七五条にいう「猥褻ノ図画」にあたるとされた事例(最判昭和58.3.8)