男性不妊と性染色質および性染色体異常にかんする研究

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Out of 682 patients who visited our male infertility clinic during two years from January of 1969 through December of 1970, 598 have received the sex chromatin test. Testicular biopsy, seminal vesiculography and determination of hormones in urine as well as chromosomal analysis were performed on chromatin-positive males. 1) Nineteen cases (3.2 %) of 598 who were recognized to have impaired spermatogenesis were found to be sex chromatin-positive males. 2) Sex chromatin-positive male was not found in oligozoospermia, but found in azoospermia only. Of 207 azoospermia, 19 (9.2 %) were found to be sex chromatin-positive males. 3) Seventy of 138 azoospermia showed germinal cell aplasia, and 16 (22.8 %) of these were found to be sex chromatin-positive males. In addition, the proliferation of Leydig cells was observed in all the sex chromatin-positive males. 4) Such findings that sex chromatin was found in 0 % to 6 % (at an average of 2.5 %) of Sertoli cells and in 5 % to 17 % (at an average of 11.0 %) of Leydig cells in testicular tissue became a useful index to make a differential diagnosis from Klinefelter's syndrome. 5) According to the classification by Ishigami and Mori, seminal vesiculograms of 19 sex chromatin-positive males were divided as follows: 2 (10.5 %) in type I, 9 (47.4 %) in type II, 5 (26.3 %) in type III and 3 (15.3 %) in type IV. The type II was the largest group in number. 6) Determination of fraction values of urinary 17-KS was performed on 19 sex chromatinpositive males and on 16 sex chromatin-negative males. As a result, no significant difference of the ratio of androsterone to etiocholanolone was observed between the two. 7) Chromosomal analysis was performed on 15 cases of sex chromatin-positive males, and 14 (93.3 %) of these were 47, XXY type. Only 1 case (6.7 %) revealed a mosaicism of 46, XY/ 47, XXY and spermatogenesis was, though very slightly, observed in the testicular tissue.

男性不妊と性染色質および性染色体異常にかんする研究

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