[症例報告]Apocrine Carcinoma of the Breast : A Case Report with Immunohistochemical Study

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A case of apocrine carcinoma of thebreast in a 66-year-old Japanese woman is herein reported. The patient was admitted to our University Hospital for a palpable left breast mass on January 17, 2000. The tumor was mildly painful and waspalpated as a 2 × 3cm oval, hard mass with relatively well-circumscribed margins located in the outer upper quadrant of the left breast. The tumor markers (CEA, CA15-3, TPA, NCC-ST-439, BBC225) were all within the normal ranges. Mammography revealed a 2 cm-opaque mass with intratumoral scattered microcalcifications and relatively well-defined margins. MR images showed a 2 cm oval mass. The tumor showed a high intensity mass on the T1-weighted image and a low intensity masson the T2-weighted image. A needle biopsy revealed apocrine carcinoma. The patient underwent Auchincloss's operative procedure. The tumor measured 1.2 cm in the greatest dimension, and appeared to be solid, gray-whitish and well-defined. The tumor showed typical histologic features of apocrine carcinoma. Immunohistochemically, the tumor showed a positive expression for AR, PR, and GCDFP-15, but a negative expression for ER, bcl-2 and p53. The tumor was classified to be Stage I(T2, NO,MO).
琉球医学会の論文