[症例報告]A Case of Paraneoplastic Cerebellar Degeneration in Small Cell Lung Cancer : Autopsy Findings after Chemoradiotherapy

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概要

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• The patient was a 62-year-old man with small cell lung cancer(SCLC). Symptoms such as dizziness, ataxia and double vision developed in the course of preoperative chemotherapy of cisplatin and VP-16. Despite the chemoradiotherapy, disabling cerebellar dysfunction developed rapidly, and operation was canceled due to poor performance status. The patient died 6 weeks after onset of the symptoms. Diagnosis of paraneoplastic cerebellar degeneration (PCD) was confirmed by autopsy which revealed a decreased number, not total loss, and degeneration of Purkinje cells in the cerebellum. Surgery could have been carried out had it not been for the cerebellar dysfunction since the cancer was at an early stage and the loss of Purkinje cells was not complete.

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