[原著］The Effects of Ethanol or Toluene on Plasma Lipids, Essential Amino Acids and Fatty Infiltration of the Liver in Wistar Male Rats
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To investigate the differenoe between the effect of alcohol (ethanol) and toluene on the plasma lipids, essential amino acids and fatty infiltration of the liver, a study was done for two months involving male wistar rats. Ethanol, 20 rats, divided into L1 (ethanol 2.5g/kg body wt), L2 (ethanol 1.25g/kg body wt) and PF, control, received isocaloric glucose and food equal to the amount taken by LI. Toluene, 20 rats, divided into 10 toluene exposed rats (Te) , 900 ppm of toluene vapour in the chamber and 10 control rats (Ce) , clean air in the chamber. Statistical analysis using Stundent's t test showed significant increase in body weight, plasma triglyceride levels, total cholesterol, high density lipoprotein (HDL) and essential amino adds caused by ethanol. Ethanol caused a significant inarease in the activity of AsT (aspartate aminotransferase) and AlT (alanine aminotransferase) and the ratio AsT/AlT. LI and L2 showed fatty infiltration of the liver, Sudan III histological staining technique. No significant differentce between L1 and L2. No effects caused on the body weight, plasma lipids, essential amino acids and AsT and AlT activities by toluene. Also toluene did not cause fatty liver in this study. From this study long terra alcohol ingestion, not toluene inhalation exposure, caused effects on the metabolism of plasma lipids, HDL and essential amino acids as well as the adverse effects on the liver structure (fatty infiltration) and AsT and AlT activities. Alcohol effects were dose independent (i. e ethanol 2.5 and 1.25 g/kg body wt did not produce different effects).
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