[原著］Thy.1^- Bone Marrow Cells Passed through Nylon Wool Can Augment the Generation of Cytotoxic T Lymphocytes (CTL) with Preference for the X-Chromosome-Linked Gene Product in Primary Cultures in vitro
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Thy.1^- bone marrow cells passed through nylon wool (NW-BM cell) helped to induce the cytotoxic T lymphocytes (CTL) specific for allogeneic major histocompatibility complex (MHC) antigens in vitro as previously reported. In this report we studied whether they could also help to induce the CTL specific to minor histocompatibility (mH) antigens. When a limited number of responder lymph node (LN) cells and an excess of helper NW-BM cells from Balb/c (H-2^d) mice were cultured with stimulator spleen cells from B10D2 mice (H-2^d), the CTL specific for mH antigens restricted to self MHC were easily induced in primary cultures in vitro. These CTL killed only B10D2 target cells but not DBA/2 (H-2^d) which had some mH antigens in common with B10D2. Genetic analysis showed that these CTL had a strict preference for X-chromosome linked gene products (Xir antigen). When responder LN cells and NW-BM cells from Balb/c mice were replaced by those from DBA/2 mice, the same results were obtained. As the CTL specific to the Xir antigen was also induced either with (B10BRxBalb/c) F1 male anti (Balb/CXB10BR) Fl male or with a reciprocal combination, stimulation across the sex chromosomes was necessary and sufficient to induce these CTL. Stimulation across other mH antigens derived from autosomes was not required as the trans-activating bystander. This report suggests that the Xir antigen has a role in immune regulation, because non-self Xir antigen is the only stimulus in this culture system.
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