[症例報告]Abnormal Hemogrobins in Ryukyu Islands : I. A Case of Hemoglobin E Trait

概要

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A case of hemoglobin E trait was detected from screening the population, 813 residents, of Henza Island, Okinawa Prefecture. The subject was an eight year old female and the abnormality has not yet been detected in other members of the family so far examined. Electrophoretic mobility of the abnormal hemoglobin component by cellulose acetate membrane electrophoresis was almost identical to that of hemoglobin A_2 and the amount of the abnormal component was 36.1 % of that of total hemoglobin. Beta chain abnormality was examined by peptide map technique and the substitution of glutamic acid at the position $ \beta $-26 by lysine was confirmed by the amino acid analyses of the purified tryptic peptides.
琉球大学医学部の論文