[原著］Changes of fibrinolytic activityin the circulating blood of patients after open heart surgery

概要

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Following surgical operations, it has beeri reported that the fibrinolytic activity may be increased in the circulating bloold. In this study, we attempted to clarify the mechanism of enhanced fibrinolytic activity related to open heart surgery. Immediately after the operation, the t-PA concentration increased gradually, and this increase in t-PA concentration continued until 24 hours after the operation. On the other hand, the FDP concentration began to increase at 2 days after the operation, and thereafter the FDP concentration increase gradually. From the above results, it is concluded that the enhanced fibrinolytic activity was based on an increased concentration of t-PA in the circulating blood. Furthermore, the increase in t-PA may have been favorable for excluding excess thrombus such as hemostatic plugs.
琉球大学医学部の論文
1986-00-00