[原著］Effects of Some Anti-Anginal Drugson Ergonovine-Induced Contractions of Isolated Dog Coronary Arteries

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Effects of some anti-anginal drugs on dog coronary arterial contractions induced by ergonovine were investigated in vitro under potassium-contracture. Administrations of phentolamine (10^<-6>g/ml) or phenoxybenzamine (3x1O^<-6>g/ml) did not affect potassium-contracture and ergonovine (10^<-6>g/ml)-induced contractions of coronary arterial strips, but phentolamine at a higher dose (10^<-5>g/ml) depressed both of them. Dihydroergotamine (10^<-7> -10^<-6>g/ml) produced further contractions of the strips under potassium-contracture and dose-dependently depressed ergonovine-induced contractions. Contractile responses to ergonovine (10^<-6>g/ml) were depressed by prior administrations of nitroglycerin (10^<-7>-10^<-6>g/ml), nifedipine (10^<-8>-10^<-7>g/ml), diltiazem(10^<-6>-10^<-5>g/ml) and SG-75 (10^<-6>-10^<-5>g/ml)in a dose-dependent fashion. Results indicate that ergonovine-induced contractions of isolated dog coronary arteries under potassium-contracture are not mediated mainly through an activation of alpha adrenoceptors and that some anti-anginal drugs such as nitroglycerin, nifedipine, diltiazem and SG-75 have a depressant action on these contractions.
琉球大学医学部の論文
1986-00-00