一過性虚血及び抗コリン薬スコポラミン誘発の学習障害に対する四物湯の改善作用及び処方解析

概要

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In the previous paper, our group reported that Shimotsu-to improved scopolamine-induced spatial cognitive deficits in rats using an 8-arm radial maze. In the present study, we investigated the effect of Shimotsu-to on the impairment induced by transient cerebral ischemia in mice in passive avoidance performance. Shimotsu-to (6.0 g/kg, p.o.) administered one hour before operation showed the protective effect on impairment induced by the cerebral ischemia reperfusion. We also studied the efficacy of Shimotsu-to and its four crude fractions, Angelica Root, Cnidium Rhizome, Peony Root and Rehmannia Root on scopolamine-induced acquisition impairment. Shimotsu-to prevented scopolamine-induced acquisition impairment at dose of 1.5 and 6.0 g/kg (p.o.). Among the four constituents, Angelica and Peony prolonged the latency of step-down and decreased the number of errors in the retention trial at a high dose (1.5 g/kg, p.o.). Whereas Rehmannia and Cnidium did not show any effect in the same performance. These results suggested that Angelica and Peony played an important role in the anti-amnesic effect of Shimotsu-to. The effect of Shimotsu-to on amnesia could not be explained entirely by the contribution of Angelica and Peony. The absence of any one of its constituents resulted in the loss of activity.
和漢医薬学会の論文
2001-06-00