A patient of non-amyloid monoclonal immunoglobulin deposition disease (MIDD) associated with multiple myeloma who rapidly developed disturbance of consciousness and multiple organ failure

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We describe a 69-year old man who developed non-amyloid monoclonal immunoglobulin deposition disease (MIDD) associated with multiple myeloma. His MIDD rapidly developed into disturbance of consciousness and multiple organ failure. Several treatments including of chemotherapy were ineffective, and no improvement in disturbed consciousness was observed and multiple organ failure progressed accompanied by pneumonia, with a outcome fatal. The autopsy revealed the depositions of IgA and λchain were observed in the stoma of the heart, pancreas, lung, liver, spleen, and kidney. These results suggest the major cause of multiple organ failure was considered to be MIDD, and the disturbed consciousness may involve in this disease