抗ヒトN-myc タンパク抗体を用いたヒト胎児中腎の免疫組織化学
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概要
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1)ヒトN-myc遺伝子特異領域がコードするタンパクに対する抗体を用い,免疫組織化学的にヒト胎児のN-mycタンパクの分布を検索した.2) N-myc遺伝子が,胎児組織内の中腎細管壁細胞に認められたExpression of a N-myc gene has been found in Wilms' tumor. N-myc protein, which is a N-myc gene product, can be detected using an anti-N-myc antibody. Paraffin sections of the fetal tissues at the seventh week of gestation were prepared for immunohistochemistry, stained by PAP method. The N-myc gene product was observed in the cells consisting of the mesonephric ductular wall. This result may suggest that Wilms' tumor is originated from the mesonephric tissue.