少量女性ホルモン(ジエチルスチルベストロール,2燐酸)による前立腺癌治療時の内分泌環境--単独およびアンチアンドロゲン(酢酸クロルマジン)との併用において--
スポンサーリンク
概要
- 論文の詳細を見る
前立腺癌患者21例にDESP 50 mgとCMA 100 mgを併用経口投与し,9例にDESP単独投与した.両群とも当初の1～3ヵ月間はテストステロン,FSH値は著明に減少し,LHは不十分ながら抑制されていた.併用群では1年間同じ値を維持していたが,単独群では6ヵ月後にテストステロンは1.0±0.5 ng/mlまで増加した.PRLは両群とも増加した.心血管系障害を併用群で6例に(内2例が死亡),単独群で2例に認めた.又併用群2例において,乳汁分泌を伴う女性化乳房をみたThe testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin levels were measured by radioimmunoassay up to one year in 21 patients with prostatic carcinoma treated with diethylstilbestrol diphosphate (DESP), 50 mg/day, and chlormadinone acetate (CMA), 100 mg/day. The purpose of this treatment was to reduce the cardiovascular side effects which were believed to occur dose-dependently and to achieve the direct drug action to the prostate gland. The same measurements were made on 9 patients treated with DESP, 50 mg/day, alone. Marked reduction of plasma testosterone and FSH levels with weaker LH suppressions was observed during the first 1-3 months in both groups. The same levels were maintained up to the end of follow-up in DESP and CMA treatment group. In the DESP treatment group, the plasma level of testosterone showed a gradual increase to 1.0 +/- 0.5 ng/ml at the sixth month. Prolactin level increased gradually in both groups. Cardiovascular side-effects were found in 29% of the patients treated with DESP and CMA and in 22% of those treated with DESP alone. In two patients in the former group gynecomastia with lactation was observed.
論文 | ランダム
- ミニシンポジウム記録 海洋高次捕食者と漁業との競合問題--食害対策における情報の共有化
- ミニシンポジウム記録 海洋動物の群れを考える--社会性・生態・遺伝子の視座から
- ミニシンポジウム記録 瀬戸内海の栄養塩不足とその対策--河川水利用技術の開発
- 塩漬条件が凍結解凍したマアジ肉の離水に及ぼす影響
- 干物のカラフトシシャモとシシャモの簡易識別法