肺, 骨転移及び高カルシウム血症を伴う腎細胞癌に対しPamidronateとインターフェロン-αの併用療法が奏効した1例

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1)高Ca血症を伴う腎細胞癌の骨及び肺転移症例を報告した. 2)Pamidronate及びIFNαの投与により血清Ca値の改善,骨溶解像の化骨化及び骨痛の消失を認めた.又,肺転移は消失した. 3)多発性骨転移,高Ca血症の症例に対しpamidronateの投与は有効であると思われたPamidronate is a second generation bisphosphonate used for treating tumor-induced hypercalcemia and for preventing the development of new bone metastasis. A 47-year-old man with renal cell carcinoma was admitted in our institution because of hypercalcemia with multiple metastasis in bone, lung and lymph nodes. After embolization of the right renal artery, the patient was treated with pamidronate and interferon-alpha. Intravenous pamidronate significantly reduced bone pain and normalized the serum calcium level. The pulmonary metastasis responded to interferon therapy after 2 months of therapy. Radical nephrectomy was then carried out. Paraaortic lymph nodes were found to be necrosed completely. Ossification of osteolytic lesions was observed after two months of therapy and metastatic lesions in the lung showed complete remission (CR) after six months of therapy.