多変量解析による腎細胞癌の予後因子の検討

概要

論文の詳細を見る
腎細胞癌104症例で,臨床的,病理学的因子について予後との関連を検討した. 1)Log-rank testでは,症状の有無, 腫瘍径, pT, N, M, pV因子, TNM stage, Robson stage, grade, 細胞型はいずれも疾患特異生存率と有意に相関していた.一方,年齢,性別,患側は相関していなかった. 2)Cox's proportional hazard modelによる多変量解析を73例に行った結果,stageのN因子(0対1～3)とM因子(0対1),及びgrade(1～2対3)のみが独立した予後因子であることが示されたIn a series of 104 patients with renal cell carcinoma, a variety of clinical and histological factors were analyzed to establish their value as prognostic factors. In a univariate analysis (log-rank test), the presence or absence of symptoms, tumor size, pT, N, M, pV categories, TNM stage, Robson stage, nuclear grade and cell type were significantly associated with cause-specific survival, while age, sex and tumor side were not. In a multivariate analysis using Cox's proportional hazard model of 73 informative cases, only N (0 vs. 1-3) and M (0 vs. 1) categories of stage and nuclear grade (1-2 vs. 3) proved to be independent prognostic markers.