脂質異常症における動脈硬化病変と関係する臓器での遺伝子発現制御：病態の進展と細胞分化関連遺伝子の発現
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脂質代謝異常症と動脈硬化を伴うマウスでの動脈硬化と関連する臓器，特に循環器系と内分泌系組織における細胞分化関連遺伝子の発現の解析した。細胞の分化や発生，臓器形成と関連するホメオボックス遺伝子などの特定の細胞分化関連遺伝子の発現制御が見られた。又，このような変化は脂質異常症や動脈硬化と関連する病態の進展と関連していたことが初めて見出された。このような研究の方向は，臨床病態の解析と治療の観点で新しい方向性を示しうる。Specific expression of cell differentiation-related genes such as homeobox family genes was found in several tissues in cardiovascular and endocrine organs. Changes in coordinate expression and aberrant expression of homeobox family genes were found in cardiovascular and endocrine tissues in hyperlipidemic mice and novel expression of these genes was related to progression of hyperlipidemic pathophysiological changes due to changes in phenotypes andcharacteristics of cardiovascular and endocrine tissues in hyperlipidemic mice as to life-stylerelated disease.
- 2010-03-01
論文 | ランダム
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