生体工学のための感光性材料の開発

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We have already developed a method to spatiotemporally control cell adhesion using a photochemical reaction. In this study, we formed cell-adhesive spots smaller than single cells and located the focal adhesions of the cells by controlling the sizes of the illuminated regions. Moreover, by subsequently illuminating the region alongside the cells patterned on the substrate in advance, their geometrical confinements were released, and migration and proliferation were induced. Single cells were also micropatterned on the substrate and were induced to extend lamellipodia or filopodia alternatively by the subsequent formation of wide or narrow paths in their surroundings, respectively. Photodegradable block copolymer composed of hydrophilic poly (ethylene oxide) (PEO) and hydrophobic poly (benzyl aspartate) connected with a photocleavable 2-nitrobezyl moiety were synthesized to form polymer micelles. Photodegradation of the resulting block copolymer was demonstrated.
神奈川大学の論文
2007-05-25