［総説］HTLV-1関連脊髄症の病態と病因 : 宿主因子・ウイルス因子の相互作用と発症への関与

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概要

• 論文の詳細を見る

• Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive myelopathy characterized by spastic paraparesis and sphincter dysfunction observed in a minority of HTLV-1 infected individuals. Previously studies indicated that HTLV-1 Tax subtype, several HLA and non-HLA genes are closely associated with the development of HAM/TSP. Two HAM/TSP associated alleles, HLA-A^*02 and HLA-DRB1^*0101 can recognize immunodominant HTLV-1 epitopes, and some HAM/TSP associated non-HLA genes are trans-activated by HTLV-1 Tax protein. Namely, complex virus-host interactions play an important role in determining the risk of HAM/TSP.

• 琉球医学会,Ryukyu Medical Associationの論文

著者

• 齊藤 峰輝

  琉球大学 医学部地域環境医科学講座免疫学分野

関連論文

• ［総説］HTLV-1関連脊髄症の病態と病因 : 宿主因子・ウイルス因子の相互作用と発症への関与

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