コイ肝細胞培養系を用いた化学物質の内分泌撹乱作用検出法の研究 ―エストロゲン類によるビテロゲニン誘導試験―
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概要
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A study on the induction test of vitellogenin (VTG) by estrogens was carried out using male and female carp(Cyprinus capio) hepatocyte cultures. Male carp hepatocytes showed a sensitive response to 17β-estradiol, ethinylestradiol, diethylstilbestrol and genistein to produce a high concentration of VTG in culture medium. Female carp hepatocytes expressed a higher background level of VTG, but showed more VTG inducibility than male cells at 1X10-aM or higher concentrations of the estrogens. Therefore, the VTG induction test using carp hepatocyte culture seems to be a useful screening methodf or estrogenic effects of chemicals.
- 2004-11-30
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