ラット大腿直筋の各種筋線維に対するLincomycinの影響 ―組織化学的研究―
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概要
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In order to clarify the mechanism by which a contracture occurs following injections of various drugs in M. rectus femoris or M. deltoicleus of human beings, the effect of lincomycin on the activity of succinic dehydrogenase (SDH) and phosphorylase (PhR) in rat rectus femoris muscle was studied histochemically. The following results were obtained. 1) It was demonstrated that rat rectus femoris muscle is composed of three types of fibers; red, white and intermediate fibers. White fibers predominate in the superficial portion of this muscle and red and intermediate fibers are located in the deeper portion. The diameter of three types of fibers was larger in the order of white＞intermediate＞red fibers. Moreover, in the cross-section of individual fibers, reticular structure (network) was observed by SDH and PhR staining. 2) One hour after injection of 65～650 mM lincomycin, SDH activity in individual fibers tended to increase. The degree of the increase was greater in the order of red≧white＞intermediate fibers. On the other hand, PhR activity was markedly inhibited by 65～650 mM lincomycin. The degree of the inhibition was greater in the order of white＞red＞intermediate fibers. Furthermore, the short diameter of individual fibers was increased by the drug and as a result the cross-section of the fibers took on an almost round appearance. This change was marked in the order of white＞red＞intermediate fibers. The intercellular space was markedly enlarged and thus each fiber tended to be separated. The destruction of the internal structure of fibers and the irregularity of the network were outstandingly prominent in white fibers, while the internal structure of the intermediate fibers remained relatively normal. 3) The structural changes mentioned above were found to be more marked 4 and 6 hours after injection of lincomycin. Three days after injection, atrophy, degeneration and necrosis were markedly observed in the individual fibers. From these results, it was histochemically induced that lincomycin affects the oxidative and glycolytic metabolism of the individual fibers, although there is a difference of the lincomycin effect between the three types of fibers, and that the drug also affects the form and the internal structure of the muscle fibers and the connective tissue surrounding the fibers.
- 1977-10-01
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