糖尿病の膵外分泌機能異常とその機序に関する研究
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概要
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Exocrine pancreatic functions by means of pancreozymin secretin test were investigated in 21 human control subjects and in 30 patients with diabetes mellitus. Next exocrine pancreatic function with pancreozymin or secretin loading test and changes of insulin and glucagon levels were studied in streptozotocin induced diabetic rats. The results obtained were as follows: 1. Significant decreases of volume, maximal bicarborate concentration and amylase output of pancreatic juice were observed in diabetic patients compared with control subjects. 2. These decreases were not related to sex, the age, and the conditions of diabetic control, duration and complications of diabetes mellitus. 3. Administration of insulin was closely related to the amelioration of amylase output, indicating that insulin would accelerate the synthesis or the secretion of the pancreatic amylase. 4. A remarkable and significant decrease of amylase output was observed in diabetic rats. An improvement of amylase output was achieved by the administration of insulin. 5. A moderate decrease of immunoreactive insulin (I) level was indicated in diabetic rats, however, immunoreactive glucagon (G) level revealed no changes. The molar ratio in G/I was higher in diabetic rats than in control rats. A significant elevation of glucagon level, on the other hand, was shown after intravenous injection of arginine to diabetic rats. In conclusion, the most important factor of the pancreatic exocrine dysfunction in diabetes mellitus was attributed to a lack of insulin action and a concomitant elevation of glucagon. An interaction of these hormones were considered.
- 1977-04-01
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